DSIP ( DS5, DS10)

Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide that induces delta sleep in mammals. Studies have shown that DSIP plasma concentrations and the human circadian rhythm are correlated and that DSIP concentrations are dependent on the initiation of sleep. Interestingly DSIP has the ability to cross the blood-brain barrier and can be absorbed from the gut.  This neuropeptide is found in plasma, peripheral organs and neurons and its functions extend beyond inducing sleep. For example it has the ability to affect levels of hormones, neurotransmitters and psychological performance. It has also been found that schizophrenia and depression patients have lower concentrations of DSIP in their cerebrospinal fluid and plasma. Clinically DFSIP has already been used to treat opioid and alcohol withdrawal in reducing symptoms felt by patients.